Can bioinformatics be used by students to research and visualize the genetic disease process?
Kathleen Gabric
(kgabric@hinsdale86.org)
(ready to use)
Coauthors
ASK
Partner Projects
| Biology Student Workbench |
Subject Areas
Grade Levels
| 9, 10, 11, 12, Undergraduate |
Unit Keywords
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genes, DNA, genetic disease, OMIM, bioinformatics, proteins, GK-12 |
Open Directory Category
Rationale of the Unit
| This project is designed to help students understand the disease process: DNA--->Genes--->Proteins--->Genetic Disease State. |
Background and Resources
Activities and Open-ended problems
ACTIVITIES OUTSIDE OF CLASS / INDEPENDENT WORK
Each student was assigned a human chromosome to research. They began at the Human Genetic Landmark website. http://www.ornl.gov/hgmis/posters/chromosome/
Students then choose a disease to report on via a webpage. Their report included a short summary of the disease, the gene's location on the chromosome, the protein(s) affected, its means of inheritance,the DNA sequence and protein sequence of the wild type, the DNA sequence and protein sequence of the disease type, and then a conclusion describing the single event that caused the disease state (ie. translocation, frameshift mutation, point mutations, etc.)
IN-CLASS ACTIVITIES -- activities and discussions within synchronous classes
Students designed a website in order to display their research and findings.
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Dialogues, Discussions, and Presentations
FACE-TO-FACE DIALOGUES
Students reviewed other students' websites for feedback before publishing. Numerous discussions occurred between students and the teacher and visiting scientist as to the mechanisms of inheritance for their particular disease.
PRESENTATIONS
Student websites were published online to be viewed by their peers and other interested parties. |
Assessment, Related Questions, and Story of the Unit
Uploaded Files:
GeneticProject.htm
cdiseaseRubric.htm
microsoft_frontpage.htm
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